Nitrofurantoin monohyd macro 100 mg caps11/28/2023 ![]() Nitrofurantoin is not indicated for the treatment of pyelonephritis or perinephric abscesses. Nitrofurantoin monohydrate/macrocrystals capsules are indicated only for the treatment of acute uncomplicated urinary tract infections (acute cystitis) caused by susceptible strains of Indications and Usage for Nitrofurantoin Capsules ![]() When nitrofurantoin monohydrate/macrocrystals capsules are administered with food, the bioavailability of nitrofurantoin is increased by approximately 40%. Nitrofurantoin is highly soluble in urine, to which it may impart a brown color. Plasma nitrofurantoin concentrations after a single oral dose of the 100 mg nitrofurantoin monohydrate/macrocrystals capsules are low, with peak levels usually less than 1 mcg/mL. Approximately 20% to 25% of a single dose of nitrofurantoin is recovered from the urine unchanged over 24 hours. Based on urinary pharmacokinetic data, the extent and rate of urinary excretion of nitrofurantoin from the 100 mg nitrofurantoin monohydrate/macrocrystals capsule are similar to those of the 50 mg or 100 mg nitrofurantoin macrocrystals capsule. The remaining 75% is nitrofurantoin monohydrate contained in a powder blend which, upon exposure to gastric and intestinal fluids, forms a gel matrix that releases nitrofurantoin over time. Twenty-five percent is macrocrystalline nitrofurantoin, which has slower dissolution and absorption than nitrofurantoin monohydrate. Nitrofurantoin Capsules - Clinical PharmacologyĮach nitrofurantoin monohydrate/macrocrystals capsule contains two forms of nitrofurantoin. 40, gelatin, lactose, magnesium stearate, povidone, talc, and titanium dioxide.įDA approved dissolution method differs from the current USP monograph dissolution methods. Inactive Ingredients: Each capsule contains carbomer 934P, corn starch, compressible sugar, D&C Yellow No. The chemical name of nitrofurantoin monohydrate is 1-methylene] amino]-2,4- imidazolidinedione monohydrate. ![]() The chemical name of nitrofurantoin macrocrystals is 1-methylene] amino]-2,4-imidazolidinedione. ![]() The nitrofurantoin monohydrate/macrocrystals capsules brand of nitrofurantoin is a hard gelatin capsule shell containing the equivalent of 100 mg of nitrofurantoin in the form of 25 mg of nitrofurantoin macrocrystals and 75 mg of nitrofurantoin monohydrate. Nitrofurantoin is an antibacterial agent specific for urinary tract infections. ![]()
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